Endocrine Abstracts

Introduction: Islets of Langerhans are well innervated and vascularized, however, the regulatory mechanisms for innervation and vascularization are not well clarified. In mice deficient for proglucagon-derived peptides (Gcg–gfp/gfp: GCGKO), islet cells that express green fluorescent protein (GFP) under the control of glucagon promoter (‘α”-cells) display hyperplasia and number of islets is increased. The present study was aimed to clarify role of the proglu...